Laboratory of Cognition and Neurobiology of Memory

The laboratory is capable of hosting projects related to behavioral and molecular biology techniques to understand the neurobiological bases of cognitive processes, learning and memory.
Structure: equipment for behavioral assessment, refrigerated centrifuges, autoclave, digital scales, micropipettors.

Coordinator

Team

Eduarda G. Nachtigall
Júlia D. R. de Freitas
Patrick N. Bergmuller
Nara R. G. Nachtigall
Thais F. Dalferth
Raissa P. Scherer
Giovana V. R. Fujita

Phone

+55 (51) 3320-5982

Lines of research

  • Effects of environmental enrichment and physical activity on memory formation and persistence. Structures and mechanisms involved in the extinction of aversive memories.
  • Structures and mechanisms involved in memory reconsolidation.
  • Structures and mechanisms involved in the formation of object-recognition and social-recognition memories.
  • Main projects
  • Modulation of fear and social-recognition memory through different pathways
  • Brain structures and cellular mechanisms involved in the effect of environmental enrichment on memory persistence

Main projects

  • Modulation of fear and social-recognition memory through different pathways
  • Brain structures and cellular mechanisms involved in the effect of environmental enrichment on memory persistence

Main articles

  • Involvement of medial prefrontal cortex canonical Wnt/β-catenin and non-canonical Wnt/Ca2+ signaling pathways in contextual fear memory in male rats.Behav Brain Res. 2022 Jul 26;430:113948. Narvaes RF, Nachtigall EG, Marcondes LA, Izquierdo I, Myskiw JC, Furini CRG. Click here
  • Role of Wnt signaling in synaptic plasticity and memory. Neurobiol Learn Mem. 2022 Jan;187:107558. Narvaes RF, Furini CRG. Click here
  • PKMζ Maintains Remote Contextual Fear Memory by Inhibiting GluA2-Dependent AMPA Receptor Endocytosis in the Prelimbic Cortex. Neuroscience. 2021 Dec 27:S0306-4522(21)00652-7. Marcondes LA, de C Myskiw J, Nachtigall EG, Narvaes RF, Izquierdo I, Furini CRG. Click here
  • The role of carbonic anhydrases in extinction of contextual fear memory. Proc Natl Acad Sci U S A. 2020 Jul 7;117(27):16000-16008. Schmidt SD, Costa A, Rani B, Godfried Nachtigall E, Passani MB, Carta F, Nocentini A, de Carvalho Myskiw J, Furini CRG, Supuran CT, Izquierdo I, Blandina P, Provensi G. Click here
  • Molecular Mechanisms in Hippocampus Involved on Object Recognition Memory Consolidation and Reconsolidation.Neuroscience. 2020 May 21;435:112-123. Furini CRG, Nachtigall EG, Behling JAK, Assis Brasil ES, Saenger BF, Narvaes RF, de Carvalho Myskiw J, Izquierdo I. Click here