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LABORATÓRIOS DE PESQUISA
Centro de Pesquisa Pré-Clínica do InsCer

O Centro de Pesquisa Pré-Clínica (CPPC) se dedica a pesquisas utilizando métodos de imagem in vivo como microtomografia computadorizada (microCT), microtomografia por emissão de pósitrons (microPET) e imagem óptica. Com foco em acompanhar processos moleculares e celulares em modelos animais, nossos objetivos incluem contribuir para o entendimento dos processos fisiopatológicos relacionados às doenças neurológicas, bem como para o desenvolvimento de novas ferramentas diagnósticas e terapêuticas. O CPPC funciona como um centro multiusuário, que fomenta a colaboração multidisciplinar utilizando ferramentas de alta tecnologia em imagem molecular.

COORDENADOR
Dra. Gianina Teribele Venturin
Dr. Samuel Greggio

LINHAS DE PESQUISA
Estudo do metabolismo cerebral in vivo

EQUIPE
Dra. Gianina Teribele Venturin
Dr. Samuel Greggio
Aluna Jaqueline Rauber Ludwig (curso de Biomedicina PUCRS)
Aluna Vitória Goulart Vargas (curso de Nutrição PUCRS)

 PRINCIPAIS ARTIGOS PUBLICADOS

1. Antidepressant Effects of Ketamine Are Not Related to 18F-FDG Metabolism or Tyrosine Hydroxylase Immunoreactivity in the Ventral Tegmental Area of Wistar Rats. Neurochem Res. 2015 Jun;40(6):1153-64. (https://link.springer.com/article/10.1007%2Fs11064-015-1576-3)
2. Ketamine promotes increased freezing behavior in rats with experimental PTSD without changing brain glucose metabolism or BDNF. Neurosci Lett. 2017 Sep 29;658:6-11. (https://www.sciencedirect.com/science/article/pii/S0304394017306742?via%3Dihub)
3. Cortical Bilateral Adaptations in Rats Submitted to Focal Cerebral Ischemia: Emphasis on Glial Metabolism. Mol Neurobiol. 2018 Mar;55(3):2025-2041. (https://link.springer.com/article/10.1007%2Fs12035-017-0458-x)
4. Depression comorbidity in epileptic rats is related to brain glucose hypometabolism and hypersynchronicity in the metabolic network architecture. 2018 May;59(5):923-934. (https://onlinelibrary.wiley.com/doi/full/10.1111/epi.14057)
5. Activated peripheral blood mononuclear cell mediators trigger astrocyte reactivity. Brain Behav Immun. 2019 Aug;80:879-888. (https://www.sciencedirect.com/science/article/pii/S088915911930039X?via%3Dihub)
6. Fructose-1,6-bisphosphate preserves glucose metabolism integrity and reduces reactive oxygen species in the brain during experimental sepsis. Brain Res. 2018 Nov 1;1698:54-61. (https://www.sciencedirect.com/science/article/pii/S0006899318303512)
7. Beneficial Effects of the Calcium Channel Blocker CTK 01512-2 in a Mouse Model of Multiple Sclerosis. Mol Neurobiol. 2018 Dec;55(12):9307-9327. (https://link.springer.com/article/10.1007/s12035-018-1049-1)
8. Nociceptin/orphanin FQ receptor modulates painful and fatigue symptoms in a mouse model of fibromyalgia. Pain. 2019 Jun;160(6):1383-1401. (https://journals.lww.com/pain/Abstract/2019/06000/Nociceptin_orphanin_FQ_receptor_modulates_painful.14.aspx)
9. Sex differences in the effects of acute stress on cerebral glucose metabolism: a microPET study. Brain Res. 2019 Nov 1;1722:146355. (https://www.sciencedirect.com/science/article/pii/S0006899319304093?via%3Dihub)
10. Increases in dendritic spine density in BLA without metabolic changes in a rodent model of PTSD. Brain Struct Funct. 2019 Nov;224(8):2857-2870. (https://link.springer.com/article/10.1007/s00429-019-01943-4)
11. Carotid arterial input function as an inverse problem in kinetic modeling of [18F]2-fluoro-2 deoxy-D-glucose (FDG). Computer Methods in Biomechanics and Biomedical Engineering: Imaging & Visualization. Aug 2019. DOI: 10.1080/21681163.2019.1647460

CONTATOS
(51) 3320.5969
[email protected]
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