RESEARCH LABORATORIES
InsCer's Pre-Clinical Research Center

The Center for Pre-Clinical Research (CPPC) is dedicated to research using in vivo imaging methods such as computed microtomography (microCT), positron emission microtomography (microPET) and optical imaging. With a focus on monitoring molecular and cellular processes in animal models, our goals include contributing to the understanding of pathophysiological processes related to neurological diseases, as well as to the development of new diagnostic and therapeutic tools. CPPC works as a multi-user center, which promotes multidisciplinary collaboration using high-tech tools in molecular imaging.

COORDINATOR
Dr. Gianina Teribele Venturin
Dr. Samuel Greggio

RESEARCH LINES
Study of brain metabolism in vivo

TEAM
Dr. Gianina Teribele Venturin
Dr. Samuel Greggio
Student Jaqueline Rauber Ludwig (Biomedical course at PUCRS)
Student Vitória Goulart Vargas (PUCRS Nutrition course)

MAIN ARTICLES PUBLISHED

1. Antidepressant Effects of Ketamine Are Not Related to 18F-FDG Metabolism or Tyrosine Hydroxylase Immunoreactivity in the Ventral Tegmental Area of ​​Wistar Rats. Neurochem Res. 2015 Jun; 40 (6): 1153-64. (https://link.springer.com/article/10.1007%2Fs11064-015-1576-3)
2. Ketamine promotes increased freezing behavior in rats with experimental PTSD without changing brain glucose metabolism or BDNF. Neurosci Lett. 2017 Sep 29; 658: 6-11. (https://www.sciencedirect.com/science/article/pii/S0304394017306742?via%3Dihub)
3. Cortical Bilateral Adaptations in Rats Submitted to Focal Cerebral Ischemia: Emphasis on Glial Metabolism. Mol Neurobiol. 2018 Mar; 55 (3): 2025-2041. (https://link.springer.com/article/10.1007%2Fs12035-017-0458-x)
4. Depression comorbidity in epileptic rats is related to brain glucose hypometabolism and hypersynchronicity in the metabolic network architecture. 2018 May; 59 (5): 923-934. (https://onlinelibrary.wiley.com/doi/full/10.1111/epi.14057)
5. Activated peripheral blood mononuclear cell mediators trigger astrocyte reactivity. Brain Behav Immun. 2019 Aug; 80: 879-888. (https://www.sciencedirect.com/science/article/pii/S088915911930039X?via%3Dihub)
6. Fructose-1,6-bisphosphate preserves glucose metabolism integrity and reduces reactive oxygen species in the brain during experimental sepsis. Brain Res. 2018 Nov 1; 1698: 54-61. (https://www.sciencedirect.com/science/article/pii/S0006899318303512)
7. Beneficial Effects of the Calcium Channel Blocker CTK 01512-2 in a Mouse Model of Multiple Sclerosis. Mol Neurobiol. 2018 Dec; 55 (12): 9307-9327. (https://link.springer.com/article/10.1007/s12035-018-1049-1)
8. Nociceptin/orphanin FQ receptor modulates painful and fatigue symptoms in a mouse model of fibromyalgia. Pain. 2019 Jun; 160 (6): 1383-1401. (https://journals.lww.com/pain/Abstract/2019/06000/Nociceptin_orphanin_FQ_receptor_modulates_painful.14.aspx)
9. Sex differences in the effects of acute stress on cerebral glucose metabolism: a microPET study. Brain Res. 2019 Nov 1; 1722: 146355. (https://www.sciencedirect.com/science/article/pii/S0006899319304093?via%3Dihub)
10. Increases in dendritic spine density in BLA without metabolic changes in a rodent model of PTSD. Brain Struct Funct. 2019 Nov; 224 (8): 2857-2870. (https://link.springer.com/article/10.1007/s00429-019-01943-4)
11. Carotid arterial input function as an inverse problem in kinetic modeling of [18F] 2-fluoro-2 deoxy-D-glucose (FDG). Computer Methods in Biomechanics and Biomedical Engineering: Imaging & Visualization. Aug 2019. DOI: 10.1080 / 21681163.2019.1647460

CONTACTS
(51) 3320.5969
[email protected]
[email protected]