Project coordinator: Eliete Biasotto Hauser, PhD

Members: Jaderson Costa da Costa, MD, PhD ; Gianina Teribele Venturin, PhD ; Samuel Greggio, PhD

The main objective of the project is to use compartment theory as mathematical modeling in the quantification of radiopharmaceutical capture, elimination and metabolization processes, based on data generated by µPET and PET technologies (microtomography and positron emission tomography). Building the input function is a necessary first step, since the radiotracer is administered intravenously. In order to apply the study in clinical research of several diseases, the work seeks to contribute to the generation of knowledge in pre-clinical research.

Check the publications about this research:

Carotid arterial input function as an inverse problem in kinetic modeling of [18F] 2- fluoro-2 deoxy-D-glucose (FDG)

Image-derived carotid arterial input fuction as an inverse problem in kinetic modeling of [18f] 2 -fluoro-2 deoxy-d-glucose (fdg) in Alzheimer's disease

Parameter estimation for kinetic modeling of 18f-fdg in positron emission tomography (pet)

E-book “Integral Methods in Science and Engineering” - Chapter 25 - Mathematical Modeling to Quantify the Pharmacokinetic Process of [18F] 2-fluor-2deoxy-D-glucose (FDG)

Laplace Transform Method for 11C-PIB Two-Tissue Reversible Compartment Model with Image-Derived Arterial Input Function