Evaluation of the expression modulation of trophic factors after transplantation of bone marrow mononuclear cells in an animal model
Project Coordinator: Jaderson Costa da Costa, MD, PhD
Researcher: Gabriele Goulart Zanirati , MSc (PhD Project) < / p>
Summary of the work: It is estimated that epilepsy affects about 1% of the world population, with approximately 30% of these patients not responding to drug treatment, becoming refractory. Within this panorama, it is essential that new therapeutic alternatives are studied and made available. Currently, stem cells represent a proposal for the treatment of epilepsy, since they have great capacity for proliferation, differentiation and production of trophic factors, and can activate mechanisms of endogenous restoration in the injured brain.
Knowing that the administration of bone marrow mononuclear cells has therapeutic potential in an experimental model of epilepsy, with this study, we aim to better understand the mechanisms of action of transplant cells, evaluating the modulation of factor secretion trophic, as well as the effects of these factors on the epileptic brain.
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