The article “Experimental Models of Neuroimmunological Disorders: A Review.”, was published last Tuesday (12) by Ana Paula Silva, doctoral student in the neuroinflammation and neuroimmunology laboratory of the Instituto do Cerebro do RS.
The study talks about immune-mediated inflammatory diseases of the central nervous system (CNS) such as: multiple sclerosis (MS), neuromyelitis optic spectrum disorders (NMOSD), acute disseminated encephalomyelitis (ADEM) and anti-NMDA receptor encephalitis (NMDAR encephalitis) and these are a group of neurological disorders that induce inflammatory and / or demyelinating lesions in the brain.
These lesions occur through a specific immune response to nerve tissue antigens, such as glial and neuronal proteins. In the last decade, many clinical, pathological, physiological and immunological aspects of neuroimmune disorders have been reported based on experimental models. Therefore, pre-clinical models have proved to be an important tool to understand the molecular and cellular mechanisms related to each disorder. In this article, the most relevant pre-clinical models in the area of ​​neuroimmunology were reviewed and related to clinical practice. Access the full text here

Timeline of advances in pre-clinical models of neuroimmune diseases.