Laboratory of Neurosciences and Electrophysiology

Is equipped for the development of projects related to electrophysiology techniques and pathophysiological mechanisms of neurological and neurodegenerative diseases.

Structure: electrophysiology setups (extracellular, intracellular and patchclamp) and cellular and molecular biology equipment

Coordinator

Team

Andrea Tavares
Daniel Marinowic
Simone Salamoni
Allan Alcará
Daniela Abreu
Fernanda Bruzzo, MD
Gutierre Neves, MD
Isadora Ghilardi
Paula Gabrielli dos Santos
Ana Paula Steinmetz
Fabio Jean de Oliveira
Felipe Krimberg
Fernanda Luccas
Fernando Tonon
Fernando Schneider
Giulia Pinzetta
João Victor de Souza
Laura Provenzi
Livia Menezes
Mariana Bartelle
Matheus Goulart
Nicole Becker
Pedro Marin
Sabrina Bizotto
Sofia Azevedo
Thomás Andrade
Vinicius Wietholter
Vitória Pimentel

 

Phone

+55 (51) 3320-5975

Lines of research

  • Pre-clinical and Clinical Epilepsy
  • Electrophysiology and ion channels
  • Regenerative Medicine and Advanced Therapies
  • Biomarkers and Therapeutic Targets
  • Neurogenetics and Pathogenic Variations
  • Cell Biology and Signaling Mechanisms
  • Nanomedicine and Extracellular Vesicles
  • Epilepsy-associated depression


Main projects

  • Electrophysiological and molecular evaluation of induced pluripotent stem cells (iPSC) from patients with mutations in the KCNQ2 gene
  • Evaluation of the profile of extracellular vesicles in patients with the SCN1A gene mutation and concomitant diagnosis of autism
  • Pharmacophysiological evaluation of the ionotropic glutamate receptor pathway in individuals with the CDKL5 gene mutation
  • Investigation of prognostic biomarkers and potential therapeutic targets in individuals with the WDR45 gene mutation
  • Evaluation of the microRNA profiles of extracellular vesicles as a therapeutic target in individuals with mTOR gene mutation
  • Autologous Bone Marrow Stem Cell Transplantation in drug-refractory temporal lobe epilepsy: Phase II Study
  • Assessment of depression in patients with temporal lobe epilepsy: epigenetic, immunohistological and molecular aspects

Mains articles

  • Stem cell-based therapy for COVID-19 and ARDS: a systematic review. Npj Regenerative Medicine, v. 6, p. 1-15, 2021. ZANIRATI, G. ; PROVENZI, L. ; LIBERMANN, L. L. ; BIZOTTO, S. C. ; GHILARDI, I. M. ; Daniel Rodrigo Marinowic ; SHETTY, A. K. ; DaCosta, J. C. Click here
  • A new SYBR Green real-time PCR to detect SARS-CoV-2. Scientific Reports, v. 11, p. 2224, 2021. MARINOWIC, D. ; ZANIRATI, G. G. ; RODRIGUES, FELIPE ; GRAHL, M. V. C. ; ALCARA, A. M. ; MACHADO, D. ; DaCosta, J.C. Click here
  • Analysis of genes involved in cell proliferation, adhesion, and control of apoptosis during embryonic neurogenesis in Induced Pluripotent Stem Cells (iPSCs) from patients with Focal Cortical Dysplasia. BRAIN RESEARCH BULLETIN, v. 155, p. 112-118, 2020. MARINOWIC, D ; MAJOLO, F. ; ZANIRATI, G. G. ; PLENTZ, I. ; Neto, Eliseu Paglioli ; Palmini, A. L. F. ; Machado, D. C. ; DaCosta J. C. Click here
  • Depression comorbidity in epileptic rats is related to brain glucose hypometabolism and hypersynchronicity in the metabolic network architecture. EPILEPSIA , v. 59, p. 923-934, 2018. ZANIRATI, GABRIELE ; AZEVEDO, PAMELLA NUNES ; VENTURIN, GIANINA TERIBELE ; Greggio, Samuel ; ALCARÁ, ALLAN MARINHO ; ZIMMER, EDUARDO R. ; FELTES, PAULA KOPSCHINA ; DACOSTA, Jaderson Costa. Click here
  • Safety and seizure control in patients with mesial temporal lobe epilepsy treated with regional superselective intra-arterial injection of autologous bone marrow mononuclear cells. Journal of Tissue Engineering and Regenerative Medicine, v. 12, p. 648-656, 2017. DaCosta, Jaderson C.; PORTUGUEZ, MIRNA W. ; MARINOWIC, DANIEL R. ; SCHILLING, LUCAS P. ; TORRES, CAROLINA M. ; DACOSTA, DANIELLE I. ; CARRION, MARIA JÚLIA M. ; RAUPP, EDUARDO F. ; Machado, Denise C. ; SODER, RICARDO B. ; LARDI, SILVIA L. ; GARICOCHEA, BERNARDO. Click here