Mechanisms involved in the control of central and peripheral inflammatory response in an experimental epilepsy model with bone marrow stem cell transplant

Research Coordinator: Jaderson Costa da Costa, MD, PhD Research Summary: Epilepsy is a brain disorder characterized by spontaneous and recurring seizures of intense, synchronized, and rhythmic firing of neuronal populations. Pronounced inflammation has been described in epileptogenic brain tissue from drug-resistant patients. Moreover, the change of the blood-brain barrier and increased expression of proinflammatory cytokines ..

Autologous Bone Marrow Stem Cell Transplant in Patients with Temporal Lobe Epilepsy Refractory to Drug Treatment: Phase II Study

Project Coordinator: Jaderson Costa da Costa, MD, PhD Members: Ricardo Vaz Breda/ Daniela Souza de Abreu/ Danielle Irigoyen da Costa/ Li Li Min/ Zaquer Suzana Munhoz Costa/ Fernando Cendes/ Alessandra Marques Pereira/ Carlos Eduardo Silvado/ Eduardo Raupp/ Denise Cantarelli Machado/ André Luis Fernandes Palmini/ Lucas P. Schilling/ Daniel Rodrigo Marinowic/ Marcos Braga Barros/ Ricardo Bernardi ..

Assessment of the Reliability and Reproducibility of Resting-State Functional Magnetic Resonance Images

Project Coordinator: Alexandre Franco, PhD Resting State, or task-free, Functional Magnetic Resonance Imaging (fMRI or rsFMRI) can evaluate the intrinsic connectivity of functional networks in healthy and/or unhealthy brains, suggesting a potential use of this method as a new biomarker for disease monitoring. In the exam, a patient relaxes, lays his/her eyes on a cross ..

OCTREO – Production of Edda HYNIC-Toc diagnostic kits

Project Coordinator: Cristina Maria Moriguchi Jeckel, PhD Most human neuroendocrine tumors express a high density of somatostatin receptors. Through the injection of octreotide, a radionuclide-labeled somatostatin analogue, it has been possible to develop a method to locate these tumors and their metastases by scintigraphy. In the project, radiopharmaceutical kits will be produced with octreotide (EDDA ..

Social Media and Decision-Making

Coordinators: PUCRS Neurophilosophy Group – Coordinators Nitamar Oliveira, PhD / Fabricio Pontin, PhD InsCer Researchers: Jaderson Costa da Costa, MD, PhD; Alexandre Franco, PhD; Augusto Buchweitz, PhD e Mirna Wetters Portuguez, PhD The purpose of “Social Media and Decision-Making”, a multidisciplinary project of the Brain Institute of Rio Grande do Sul is to investigate how ..

Sleep Research – Brazilian children and adolescents

Research Coordinator: Magda Lahorgue Nunes, PhD In order to evaluate key features of the sleep of Brazilian children and adolescents, the Brain Institute of Rio Grande do Sul – PUCRS is developing a pioneer study on children from one month to 19 years of age. The research Evaluation of sleep characteristics and prevalence of disorders ..

ACERTA Project

Project Coordinator: Augusto Buchweitz, PhD The ACERTA project was created to pursue a better understanding of the changes that occur in children’s brains during literacy development. The main objective is to understand why some children develop learning disorders. In collaboration with two other research centers in Florianópolis and Natal (Brazil), early biomarkers of these disorders are ..

Electrophysiology and Patch-Clamp: technique to measure electrical activity in isolated ion channels

Project Coordinator: Célia Carlini, PhD Guest Researcher: Vitya Vardanyan, PhD, from the Institute of Molecular Biophysics of the National Academy of Sciences of Armenia Patch-Clamp is a powerful technique to study the electrical activity of cells, in particular neurons, the main cells of the nervous system. Bioelectrogenesis, the ability of cells to generate electrical currents ..

Test Your Brain

Project Coordinator: Mirna Wetters Portuguez, PhD Members: Sabine Possa Marroni, MSc (PhD Project in progress), Paul Bertram Garcia, Ingrid Louise and Karen Wolfart Chies. With the advancement of technology, application resources are practical tools that can easily be used by health professionals for patient assessment and data storage. Test Your Brain is a mobile app ..