Avaliação da migração e neurodiferenciação de células-tronco pluripotentes induzidas (iPS) de pacientes com displasia cortical

Coordenador do Projeto: Jaderson Costa da Costa, MD, PhD Pesquisador: Daniel Marinowic, PhD Resumo do Trabalho: A Displasia Cortical é uma das formas mais frequentes de malformações do desenvolvimento cortical. Alterações no tráfego celular estão presentes em diversas doenças neurológicas, inclusive epilepsia refratária a medicação e displasiasl. A reprogramação de células somáticas adultas é uma abordagem atraente e ..

In-vivo molecular imaging of the migration, distribution and survival of stem cells in an animal model of epilepsy

Project Coordinator: Jaderson Costa da Costa, MD, PhD Research Summary: strategies to promote an increase in the number and function of endogenous regenerative cells, or to introduce cells with regenerative potential in the central nervous system (CNS) may represent important alternatives in the treatment of neurological diseases. Thus, stem cell transplantation arises as a promising ..

Biomarkers in the cognitive continuum of the elderly (CCE): neural networks, functional plasticity and hippocampal volume in older adults in the community

Project Coordinator: André Luis Fernandes Palmini, MD, PhD Research Summary: Advanced age is the main risk factor for degenerative brain diseases. Older adults in the community vary in risk of progression along the cognitive continuum of the elderly (CCE). The project will test senior citizens between 70 and 80 years of age, including educational and ..

Development of Fast and Robust Dynamic MRI Techniques using Compressed Sensing for Evaluation of Cystic Fibrosis

Special Visiting Professor: Ricardo Otazo, PhD (New York University) InsCer Coordinators: Augusto Buchweitz, PhD and Alexandre R. Franco, PhD Research Summary: The project aims to develop and validate fast and motion-robust magnetic resonance imaging techniques, with high spatial and temporal resolution for (a) better assessment of cystic fibrosis patients without the risks of radiation and ..

Evaluation of microglial activation by PET/CT and its association with the appearance of lesions on MRI in patients with relapsing-remitting multiple sclerosis undergoing fingolimode therapy

Project Coordinator: Jefferson Becker, MD, PhD Research Summary: Multiple sclerosis (MS) is the most common inflammatory disease of the central nervous system (CNS), characterized by considerably varying clinical and pathological manifestations. Several pathological studies on Multiple Sclerosis have shown that myelin and its supporting cells, oligodendrocytes, are usually destroyed in MS lesions. White matter lesions ..

Effect of interleukin-1 Beta on the therapeutic potential of bone marrow mononuclear cells in experimental epilepsy

Project Coordinator: Zaquer Suzana Munhoz Costa-Ferro, PhD Research Summary: In this study, we will evaluate the expression of interleukin 1 beta (IL-1β) on LTP after the induction of status epilepticus (SE) and injection of bone marrow mononuclear cells. The specific objectives are: transplant bone marrow mononuclear cells (BMMC) after SE in experimental models; evaluate the ..

Granulocyte colony-stimulating factor (GCSF) treatment in epilepticus rats

Project Coordinator: Zaquer Suzana Munhoz Costa-Ferro, PhD Research Summary: In this study, the effect of G-CSF on spontaneous recurrent seizures (SRS) will be assessed and compared with the effect of bone marrow mononuclear cells (BMMCs). The specific objectives are to treat animals with G-CSF; transplant BMMCs into experimental models of epilepsy; evaluate SRS; evaluate apoptosis, ..

Assessment of the modulation of trophic factor expression after the transplantation of bone marrow mononuclear cells into an animal model with pilocarpine-induced chronic epilepsy

Project Coordinator: Jaderson Costa da Costa, MD, PhD Researcher: Gabriele Goulart Zanirati, MSc (PhD Project) Research Summary: Epilepsy is estimated to affect about 1% of the world population, and approximately 30% of these patients do not respond to drug treatment, becoming refractory. In this scenario, the study and availability of new therapeutic options is essential. ..

Assessment of the permeability of the blood-brain barrier in an experimental model of posterior reversible encephalopathy syndrome through neuroimaging

Project Coordinator: Luiz Carlos Porcello Marrone, MD, MSc (PhD Project in progress) and Jaderson Costa da Costa, MD, PhD Research Summary: The Posterior Reversible Encephalopathy Syndrome (PRES) is a clinical-radiological state characterized by headache, altered level of consciousness, seizures and visual alteration and is associated with a vasogenic edema in the brain white matter, affecting ..

Neurotoxic activity of ureases and derived peptides

Project Coordinator: Célia Regina R. S. Carlini, PhD Research Summary: Ureases are enzymes produced by plants, fungi and bacteria that hydrolyze urea into ammonia and CO2. Besides being toxic for generating ammonia, ureases have other biological properties independent of enzyme action, such as proinflammatory activity and neurotoxicity. Plant ureases have biotechnological potential as biopesticides, and ..